UV-Induced Gene Expression — Fos/AP-1 Suppression (Mouse)

Category: UV Protection & Photoaging

Journal: Photomedicine and Laser Surgery (2015)

Key finding

Red light pretreatment significantly reduced UV-induced Fos (AP-1) expression (p<0.01), a key driver of MMP-mediated collagen breakdown and DNA damage after UV exposure. Red light more often caused opposite gene expression to UV.

Protocol

• Wavelength: 670 nm
• Irradiance: 8 mW/cm²
• Dose: 2.5 J/cm² per session
• Duration: 3 sessions over 24 h before UV exposure

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